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产品中心 药物靶点和Fc受体 药物靶点

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TNFSF15 His Tag Protein, Rhesus macaque

Tumor necrosis factor ligand superfamily member 15,TNF ligand-related molecule 1,Vascular endothelial cell growth inhibitor,TNLG1B

价格 ￥500.00 （ 1-2周）
货号 UA019004
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rhesus macaque

  • 分子别名

    Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, TNLG1B

  • Accession

    F6S8F9

  • 表达序列

    Protein sequence (F6S8F9, Leu72-Leu251, with N-His Tag) LKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHLKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFVYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 22.1 kDa Observed MW: 25-30 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • TNFSF15 (Tumor Necrosis Factor Superfamily Member 15), also known as TL1A, is a cytokine that binds to death receptor 3 (DR3) and decoy receptor 3 (DcR3). It plays a key role in modulating immune responses, particularly in T-cell activation, inflammation, and autoimmune diseases. TNFSF15 is highly expressed in endothelial cells and contributes to angiogenesis and vascular remodeling. Dysregulation of TNFSF15 is linked to inflammatory disorders (e.g., Crohn’s disease, rheumatoid arthritis) and cancers. Its dual role in pro-inflammatory and anti-angiogenic signaling makes it a potential therapeutic target for immune-mediated and vascular diseases.

  • 生物活性

    • Immobilized DcR3/TNFRSF6B Protein, Human (hFc) at 2 μg/mL (100 μL/well) can bind Rhesus macaque TNFSF15 Protein, His Tag with EC50 of 7.7-10.3 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions; NR: non-reducing conditions）

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