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产品中心 药物靶点和Fc受体 药物靶点

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IL-10 His Tag Protein, Human

价格 ￥1,800.00 （ 1-2周）
货号 UA019002
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • Accession

    P22301

  • 表达序列

    SENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRNGGGGSHHHHHHHHHH.

  • 表达宿主

    HEK293

  • 分子量

    19.6 kDa (Reducing)

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    0.2M PBS, pH7.4

  • 溶解方法

    Reconstitute at less than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    Use within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles.

背景介绍

  • IL-10 (Interlukin-10) is a multicellular and multifunctional cytokine that regulates cell growth and differentiation, participates in inflammatory and immune responses, and is recognized as an inflammatory and immunosuppressive factor. It plays an important role in tumor, infection, organ transplantation, hematopoietic system and cardiovascular system, and is closely related to diseases of blood, digestion, especially cardiovascular system.Overexpression of IL-10 leads to skin leishmaniasis, and IL-10 plays a decisive role in the development of immune paralysis, temporary immune deficiency after trauma, major surgery, burns, shock and high risk bacterial/fungal infections that can be fatal. Macrophage-derived IL-10 is also associated with age-related immune deficiency.Continuous immune activation occurs when IL-10 is relatively or absolutely deficient, which can lead to chronic inflammatory bowel diseases (such as Crohn's disease), psoriasis, rheumatoid arthritis and post-transplant disease, etc.This product is the recombinant human IL-10 protein expressed from human 293 cells (HEK293).

  • 生物活性

    • Immobilized Human IL-10, His Tag at 20 μg/mL (50 μL/well) can bind Active Recombinant Human IL-10 R alpha/IL10RA/CD210 Protein with EC50 of 29.35-35.61 ng/mL.

    • The ELISA based assay shows that Human IL-10, His tag is stable after freezing and thawing 3 times.

    • The ELISA based assay shows that Human IL-10, His Tag (S0A4001) is stable at 4°C for 4 weeks.

  • 电泳

    • 1μg（R: reducing conditions）

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