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产品中心 药物靶点和Fc受体 药物靶点

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Plectin His Tag Protein, Rhesus macaque/Cynomolgus

PCN, PLTN,Plectin-1,PLEC1

价格 ￥1,390.00 （ 供应商现货 ： 3-5个工作日）
货号 UA016101
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus, Rhesus macaque

  • 分子别名

    PCN, PLTN, Plectin-1, PLEC1

  • Accession

    Rhesus macaque :F7ABN9, Cynomolgus: XP_065375884.1

  • 表达序列

    Rhesus macaque :Ala4555-Ala4862 with His Tag at the N-Terminus
    Cynomolgus:Ala4394-Ala4701 with His Tag at the N-Terminus

  • 表达宿主

    HEK293

  • 分子量

    40-60kDa (Reducing)

  • 纯度

    ＞90% by SDS-PAGE

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Natsuga K, Nishie W, Akiyama M, Nakamura H, Shinkuma S, McMillan JR, Nagasaki A, Has C, Ouchi T, Ishiko A, Hirako Y, Owaribe K, Sawamura D, Bruckner-Tuderman L, Shimizu H. Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex. Hum Mutat. 2010 Mar;31(3):308-16.
    2.Tu WT, Chen PC, Hou PC, Huang HY, Wang JY, Chao SC, Lee JY, McGrath JA, Natsuga K, Hsu CK. Plectin Missense Mutation p.Leu319Pro in the Pathogenesis of Autosomal Recessive Epidermolysis Bullosa Simplex. Acta Derm Venereol. 2020 Aug 18;100(15):adv00242.

背景介绍

  • Plectin is a large cytolinker protein composed of an N-terminal actin-binding domain, a central rod-shaped α-helical coiled-coil region, and a C-terminal intermediate filament-binding domain, with multiple alternatively spliced isoforms enabling diverse subcellular localization; its functional core lies in bridging microfilaments, intermediate filaments, and microtubule networks to maintain cellular mechanical stability, while also participating in hemidesmosome assembly, myofibril integrity maintenance, and signal transduction regulation. Clinically, PLEC gene mutations cause epidermolysis bullosa simplex (EBS) and its variant subtypes with muscular dystrophy, pyloric atresia, or cardiomyopathy, collectively termed "plectinopathies," with pathological mechanisms involving dermal-epidermal junction disruption, desmin aggregation in muscle fibers, and mitochondrial dysfunction, while recent therapeutic strategies such as chemical chaperone approaches have provided new directions for treatment.

  • 电泳

    • 1μg (R: reducing condition, N:non-reducing condition).

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