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物种
Human分子别名
CD201, APC receptor, CCCA, CCD41Accession
Q9UNN8表达序列
Ser18-Ser210 with His Tag at the C-Terminus
表达宿主
HEK293分子量
35-40kDa (Reducing)纯度
＞95% by SDS-PAGE & HPLC标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4, 5% trehalose
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1. Wang H, March L, Jackson CJ, Cross M, Xue M. EPCR in Wound Healing: Mechanisms of Action and Therapeutic Potential. Cells. 2026 Mar 22;15(6):567.
2. Song H, Li Q, Gui X, Fang Z, Zhou W, Wang M, Jiang Y, Geng A, Shen X, Liu Y, Zhang H, Nie Z, Zhang L, Zhu H, Zhang F, Li X, Luo F, Zhang H, Shen W, Sun X. Endothelial protein C receptor promotes retinal neovascularization through heme catabolism. Nat Commun. 2025 Feb 13;16(1):1603.
3. Chambers SEJ, Guduric-Fuchs J, Pedrini E, Bertelli PM, Charoensuk C, Peixoto E, Pathak V, Alhamdan HI, Xie R, Krasnodembskaya A, Lechner J, Stitt AW, Medina RJ. Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity. Angiogenesis. 2025 May 23;28(3):30.
EPCR (PROCR/CD201/activated protein C receptor) is a type I transmembrane N-glycosylated glycoprotein structurally related to the MHC class I/CD1 superfamily, featuring an extracellular domain with two α-helices and eight β-strands forming a hydrophobic lipid-binding groove. It is highly expressed on endothelial cells of arteries and veins in heart and lung, as well as on various stem/progenitor cells. Functionally, EPCR enhances protein C activation to APC by the thrombin-thrombomodulin complex, regulating coagulation; it also mediates cytoprotective signaling via PAR1, promoting cell proliferation, angiogenesis, and anti-inflammatory responses. A soluble form (sEPCR) is released by metalloproteases such as ADAM17. Clinically, EPCR represents a promising therapeutic target—its inhibition attenuates pathological retinal neovascularization, while APC-EPCR axis activation shows efficacy in wound healing, sepsis, and retinal protection, with non-anticoagulant APC variants being developed to minimize bleeding risks.
电泳
1μg (R: reducing condition, N:non-reducing condition).
体积排阻色谱(SEC-HPLC)
The purity of EPCR/PROCR His Tag Protein, Human is more than 95% determined by SEC-HPLC.
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