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产品中心 药物靶点和Fc受体 药物靶点

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FITC-Labeled TSLP His Tag Protein, Human

Thymic stromal lymphopoietin

价格 ￥2,320.00 （ 1-2周）
货号 UA016092
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Thymic stromal lymphopoietin

  • Accession

    Q969D9

  • 表达序列

    Tyr29-Gln159 with His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    9-14&18-27kDa (Reducing)

  • 标记

    FITC

  • 标签

    His Tag

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4

  • 储存条件

    · 12 months from date of receipt stored at -20 to -80℃.
    · 1 week, 2 to 8℃ under sterile conditions.
    · Recommend to aliquot the protein into smaller quantities for optimal storage.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Kui L, Huang J, Wang G, Zhao J, Wang S, Qin X, Liu L, Hu J, Chen L, Wang X, Li Q, Zhao Y, Tang Y, Xiong K, Zhan S, Ding H, Wang J, Cai H, Zhang Q, Zi X, Deng Q, Gao L, Wang X, Zou C, Yang H, Xiao Y, Yang B, Leng B, Zhang L, Hu G. Endolysin significantly improves symptoms with atopic dermatitis: bridging the gap from research to clinical practice. Front Immunol. 2025 Oct 22;16:1667195.
    2.Liu YJ, et al. (2007) TSLP: An Epithelial Cell Cytokine that Regulates T Cell Differentiation by Conditioning Dendritic Cell Maturation. Annual Review of Immunology. 25: 193-219.

背景介绍

  • Thymic stromal lymphopoietin (TSLP) is a cytokine secreted by epithelial cells, encoded by a gene that produces a 159-amino acid precursor protein. This protein plays a dual regulatory role in the immune system: on one hand, it promotes type 2 T-helper cell immune responses by activating dendritic cells and directly acts on immune cells such as basophils, driving the development of allergic diseases like atopic dermatitis and asthma; on the other hand, it is involved in maintaining intestinal homeostasis and central immune tolerance. Due to its central role in allergic diseases, TSLP has become an important therapeutic target for conditions such as atopic dermatitis and asthma.

注意事项
  • Please strictly follow the recommended dosage for experiments. If the population clustering is not distinct, the recommended dosage may be appropriately increased by 2-5 folds.

  • 流式分析

    • 2e5 of transient transfected anti- TSLP ScFv CAR-293 cells were stained with 0.5ug FITC-Labeled TSLP His Tag Protein, Human, (Cat. No. UA016092) and unlable respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). FITC signal was used to evaluate the binding activity.2e5 of transient transfected anti- TSLP ScFv CAR-293 cells were stained with isotype and Whitlow/218 Linker-Alexa Fluor® 488 (Fig. D and E). Alexa Fluor® 488 signal was used to evaluate the binding activity.

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