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产品中心 药物靶点和Fc受体 药物靶点

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Biotinylated IL-2 His Tag Protein, Human

Interleukin-2,T-cell growth factor (TCGF),Aldesleukin

价格 ￥2,580.00 （ 供应商现货 ： 3-5个工作日）
货号 UA016086
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Interleukin-2, T-cell growth factor (TCGF), Aldesleukin

  • Accession

    P60568-1

  • 表达序列

    Ala21-Thr153 with His&Avi Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    15-20kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE,> 85% by HPLC

  • 活性

    Immobilized IL-2R alpha/CD25 Fc Chimera Protein, Human (Cat. No. UA010260) at 5.0μg/mL (100μL/well) can bind Biotinylated IL-2 His Tag Protein, Human (Cat. No. UA016090) with EC50 of 3.67-5.89 ng/mL.

  • 标记

    Biotin

  • 标签

    Avi Tag, His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Shouse AN, LaPorte KM, Malek TR. Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer. Immunity. 2024 Mar 12;57(3):414-428.
    2.Arenas-Ramirez N, Woytschak J, Boyman O. Interleukin-2: Biology, Design and Application. Trends Immunol. 2015 Dec;36(12):763-777.

背景介绍

  • IL-2 is a powerful immunoregulatory lymphokine produced by T cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid including one intrachain disulfide bond.

  • 电泳

    • 1μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of Biotinylated IL-2 His Tag Protein, Human is more than 85% determined by SEC-HPLC.

  • ELISA

    • Immobilized IL-2R alpha/CD25 Fc Chimera Protein, Human(Cat. No. UA010260) at 5.0μg/mL (100μL/well) can bind Biotinylated IL-2 His Tag Protein, Human(Cat. No. UA016090) with EC50 of 3.67-5.89 ng/mL.

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