热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/4）

Prolactin R/PRLR Fc Chimera Protein, Human

Prolactin receptor,PRL-R

价格 ￥1,290.00 （ 供应商现货 ： 3-5个工作日）
货号 UA016068
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Prolactin receptor, PRL-R

  • Accession

    P16471

  • 表达序列

    Gln25-Asp234 with hIgG1 Fc Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    55-70kDa (Reducing)

  • 纯度

    ＞90% by SDS-PAGE,> 80% by HPLC

  • 活性

    Immobilized Human PRL, His tag (Cat. No. S0A0016) at 1.0μg/mL (100μL/well) can bind Prolactin R/PRLR Fc Chimera Protein, Human (Cat. No. UA016068) with EC50 of 4.11-7.47 ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Harris J, Stanford PM, Oakes SR, Ormandy CJ. Prolactin and the prolactin receptor: new targets of an old hormone. Ann Med. 2004;36(6):414-25.
    2.Brooks CL. Molecular mechanisms of prolactin and its receptor. Endocr Rev. 2012 Aug;33(4):504-25.

背景介绍

  • Prolactin receptor (PRLR) is a member of the cytokine receptor superfamily, composed of an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular signaling domain, with three isoforms (long, short, and intermediate). Upon binding to prolactin, it activates the JAK2-STAT5 signaling pathway to regulate physiological processes including mammary gland development, lactation, metabolism, and immune modulation. Clinical studies have demonstrated that PRLR is highly expressed in various tumors such as breast and prostate cancers, promoting cancer cell proliferation, invasion, and drug resistance through autocrine/paracrine loops, making it an emerging therapeutic target for antitumor treatment, with monoclonal antibodies and small molecule antagonists currently under clinical development.

  • 电泳

    • 2μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of Prolactin R/PRLR Fc Chimera Protein, Human is more than 80% determined by SEC-HPLC.

  • ELISA

    • Immobilized Human PRL, His tag (Cat. No. S0A0016) at 1.0μg/mL (100μL/well) can bind Prolactin R/PRLR Fc Chimera Protein, Human (Cat. No. UA016068) with EC50 of 4.11-7.47 ng/mL.

    • Immobilized Human GH Protein, His Tag (Cat. No. S0A8004) at 2.0μg/mL (100μL/well) can bind Prolactin R/PRLR Fc Chimera Protein, Human (Cat. No. UA016068) with EC50 of 3.3-4.4 ng/mL.

评论(0)