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产品中心 药物靶点和Fc受体 药物靶点

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CLEC7A His Tag Protein, Cynomolgus

BGR,CANDF4,CD369,CLECSF12,DECTIN1,SCARE2

价格 ￥1,460.00 （ 供应商现货 ： 3-5个工作日）
货号 UA016065
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2

  • Accession

    A0A2K5UXY6

  • 表达序列

    Thr 100 - Met 281 with His Tag at the N-Terminus

  • 表达宿主

    HEK293

  • 分子量

    35-40kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive hybridization. Journal of Biological Chemistry, 275(26), 20157-20167.
    2. The human beta-glucan receptor is widely expressed and functionally equivalent to murine dectin-1. Journal of Immunology, 167(8), 4567-4573.
    3. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nature Immunology, 8(1), 31-38.

背景介绍

  • The CLEC7A gene in cynomolgus macaque (Macaca fascicularis) encodes a Dectin-1 protein highly homologous to its human counterpart. According to the KEGG pathway database, the cynomolgus macaque CLEC7A gene is designated with the identifier 103218570, and the encoded protein is classified as a C-type lectin receptor family member.

    Structural and Functional Homology: As a non-human primate model, cynomolgus macaque Dectin-1 is highly conserved in structure and function with the human protein. It is a type II transmembrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic ITAM motif. This receptor recognizes pathogen-derived β-glucans, activates downstream signaling cascades, induces inflammatory cytokines and chemokines, and triggers innate and adaptive immune responses against pathogens

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of CLEC7A His Tag Protein, Cynomolgus is more than 95% determined by SEC-HPLC.

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