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产品中心 药物靶点和Fc受体 药物靶点

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CLEC7A His Tag Protein, Human

BGR,CANDF4,CD369,CLECSF12,DECTIN1,SCARE2

价格 ￥1,450.00 （ 供应商现货 ： 3-5个工作日）
货号 UA016064
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2

  • Accession

    Q9BXN2-2

  • 表达序列

    Thr 66 - Met 201 with His Tag at the N-Terminus

  • 表达宿主

    HEK293

  • 分子量

    15-25kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Alveolar macrophages drive lung fibrosis by sensing translocated gut fungi via Dectin-1-Raf1 axis. Immunity.
    2. Targeting Dectin-1 and/or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model. Cellular Oncology, 47(4), 1-14.
    3. Dectin-1 (CLEC-7A) and Mincle (CLEC-4E) suppress protective responses of macrophages during mycobacterial infection. Journal of Leukocyte Biology, 117(11), qiaf146.

背景介绍

  • CLEC7A (C-type lectin domain family 7 member A) encodes the protein Dectin-1, a key member of the C-type lectin receptor family that functions as a pattern recognition receptor central to antifungal immunity. The gene is located on human chromosome 12p13.2 and is broadly expressed in tissues including bone marrow and appendix.

    Structure and Isoforms: Dectin-1 is a type II transmembrane glycoprotein of approximately 28 kDa, containing an extracellular C-type lectin-like domain (CRD), a transmembrane region, and a cytoplasmic domain. The cytoplasmic tail harbors an immunoreceptor tyrosine-based activation motif (ITAM) essential for signal transduction. Alternative splicing generates at least eight isoforms (A-H), with isoform A representing the full-length functional form; isoform B lacks the stalk region, while others harbor deletions or insertions in the CRD or transmembrane domains.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of CLEC7A His Tag Protein, Human is more than 95% determined by SEC-HPLC.

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