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产品中心 药物靶点和Fc受体 药物靶点

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TDGF1/Cripto His Tag Protein, Human

CRIPTO-1,TDGF1

价格 ￥1,410.00 （ 供应商现货 ： 3-5个工作日）
货号 UA016040
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CRIPTO-1, TDGF1

  • Accession

    P13385

  • 表达序列

    Leu31-Thr172 with His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    25-35kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & HPLC

  • 活性

    ALK4 (24-126) Fc Chimera Protein, Human captured on Protein A Chip can bind TDGF1/Cripto His Tag Protein, Human (Cat. No. UA016040) with an affinity constant of 0.23 μM as determined in SPR assay.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Freeman, D.W., et al. (2021). Whence CRIPTO: The Reemergence of an Oncofetal Factor in 'Wounds' That Fail to Heal. International Journal of Molecular Sciences, 22(18), 10164.
    2. Karkampouna, S., et al. (2025). CRIPTO’s multifaceted role in driving aggressive prostate cancer unveiled by in vivo, organoid, and patient data. Oncogene, 44, 462-475.
    3. TDGF1 Mediates the Oncogenic Effects of the OLMALINC/miR-3614-5p ceRNA Axis in Colon Cancer Through Nodal/Smad2 and Glypican-1/MAPK-AKT Signaling.

背景介绍

  • TDGF1 (Teratocarcinoma-Derived Growth Factor 1) encodes a protein more widely known as CRIPTO (or CR-1). It is the founding member of the vertebrate EGF-CFC (Epidermal Growth Factor-Cripto/FRL-1/Cryptic) gene family. TDGF1 is a GPI-anchored cell membrane protein that can also be shed as a soluble form. Its protein structure contains an EGF-like domain.

    As an oncofetal protein, TDGF1/CRIPTO plays a critical role in embryonic development, potentially determining the differentiation of epiblastic cells into mesoderm. In tumorigenesis, TDGF1/CRIPTO is "reactivated" or aberrantly overexpressed in various cancers, including prostate, colon, lung, and breast cancers. Its functions include promoting tumor initiation and progression, driving tumor aggressiveness, and maintaining stem cell properties and cellular plasticity. At the signaling level, TDGF1/CRIPTO is a key co-receptor for the Nodal signaling pathway. It interacts with the Activin type-1 receptor (ACVR1B) and modulates SMAD2/3 activation. Furthermore, it can exert oncogenic effects through various signaling axes, such as Nodal/Smad2 and Glypican-1/MAPK-AKT. Consequently, TDGF1/CRIPTO has become a promising tumor biomarker and therapeutic target.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of TDGF1/Cripto His Tag Protein, Human is more than 95% determined by SEC-HPLC.

  • SPR

    • ALK4 (24-126) Fc Chimera Protein, Human captured on Protein A Chip can bind TDGF1/Cripto His Tag Protein, Human (Cat. No. UA016040) with an affinity constant of 0.23 μM as determined in SPR assay.

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