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产品中心 药物靶点和Fc受体 药物靶点

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CD3 gamma His Tag Protein, Human

CD3 gamma,CD3G

价格 ￥1,380.00 （ 供应商现货 ： 3-5个工作日）
货号 UA016025
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CD3 gamma, CD3G

  • Accession

    P09693

  • 表达序列

    Gln 23 - Ser 116 with His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    15-25kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. The role of the different CD3γ domains in TCR expression and signaling. Frontiers in Immunology, 13, 978658.
    2. Signal transduction by lymphocyte antigen receptors. Cell, 76(2), 263–274.
    3. Deconstructing the form and function of the TCR/CD3 complex. Immunity, 24(2), 133–139.

背景介绍

  • CD3γ (Cluster of Differentiation 3 gamma) is a critical subunit of the T cell receptor (TCR) complex. It is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. The CD3γ chain, together with CD3δ, CD3ε, and the CD3ζ homodimer, forms the invariant CD3 signaling module that associates with the variable TCRαβ or TCRγδ chains.

    The primary function of CD3γ is to mediate signal transduction upon antigen recognition. Like other CD3 subunits, CD3γ contains three immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic domain. Upon TCR engagement with peptide-MHC complexes, these ITAMs are phosphorylated by Src-family kinases (LCK and FYN), initiating downstream signaling cascades that lead to T cell activation, proliferation, and differentiation.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of CD3 gamma His Tag Protein, Human is more than 95% determined by SEC-HPLC.

  • 反相高效液相色谱(RP-HPLC)

    • The purity of CD3 gamma His Tag Protein, Human is more than 95% determined by RP-HPLC.

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