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产品中心 药物靶点和Fc受体 药物靶点

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FGF R3 (IIIc) Fc Chimera Protein, Human

FGF R3C,CD333,FGFR-3,FGFR3,JTK4

价格 ￥1,460.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011374
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    FGF R3C,CD333,FGFR-3,FGFR3,JTK4

  • Accession

    P22607-1

  • 表达序列

    Glu23-Gly375 with hIgG1 Fc Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    80-95kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & > 80% by SEC-HPLC

  • 活性

    Immobilized FGF-basic(146aa) Protein, Human (Cat. No. UA040145) at 2.0μg/mL (100μL/well) can bind FGF R3 (IIIc) Fc Chimera Protein, Human (Cat. No. UA011374) with EC50 of 1.91-21.85 ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Li R, Linscott J, Catto JWF, Daneshmand S, Faltas BM, Kamat AM, Meeks JJ, Necchi A, Pradere B, Ross JS, van der Heijden MS, van Rhijn BWG, Loriot Y. FGFR Inhibition in Urothelial Carcinoma. Eur Urol. 2025 Feb;87(2):110-122.
    2.Asada N, Tanaka Y, Hayashido Y, Toratani S, Kan M, Kitamoto M, Nakanishi T, Kajiyama G, Chayama K, Okamoto T. Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines. In Vitro Cell Dev Biol Anim. 2003 Jul-Aug;39(7):321-8.

背景介绍

  • FGFR (fibroblast growth factor receptor) is a class of transmembrane proteins that consist of three immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain. They transmit signals through ligand-induced dimerization and autophosphorylation, regulating cell growth and differentiation. Clinically, particularly in the case of FGFR3, gene alterations, abnormal expression (such as upregulation in epithelial tumors), and its activation of the PLCγ signaling pathway are closely associated with tumor development and resistance to endocrine therapies (such as tamoxifen), making it an important therapeutic target for cancer treatment.

  • 电泳

    • 2μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of FGF R3 (IIIc) Fc Chimera Protein, Human is more than 80% determined by SEC-HPLC.

  • ELISA

    • Immobilized FGF-basic(146aa) Protein, Human (Cat. No. UA040145) at 2.0μg/mL (100μL/well) can bind FGF R3 (IIIc) Fc Chimera Protein, Human (Cat. No. UA011374) with EC50 of 1.91-21.85 ng/mL.

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