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产品中心 药物靶点和Fc受体 药物靶点

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IL-21 R His Tag Protein, Human

IL21R,CD360,NILR

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011349
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    IL21R, CD360, NILR

  • Accession

    Q9HBE5-1

  • 表达序列

    Cys20-Pro236 with His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    35-50kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & > 95% SEC-HPLC

  • 活性

    Immobilized IL-21 Protein, Human (Cat. No. UA040009) at 1.0μg/mL (100μL/well) can bind IL-21 R His Tag Protein, Human (Cat. No. UA011349) with EC50 of 31.42-83.36 ng/mL.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Andersen KG, Shylakhter I, Tabrizi S, Grossman SR, Happi CT, Sabeti PC. Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever. Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):868-77.
    2.Collins M, Whitters MJ, Young DA. IL-21 and IL-21 receptor: a new cytokine pathway modulates innate and adaptive immunity. Immunol Res. 2003;28(2):131-40.

背景介绍

  • IL-21 receptor (IL-21R/CD360/NILR) belongs to the type I cytokine receptor family, subfamily 4. It is a single-pass transmembrane protein composed of two fibronectin type-III domains, a WSXWS folding motif and a Box1 JAK-binding motif, and together with the common γ-chain it forms the high-affinity IL-21 receptor complex. Selectively enriched in thymus and spleen, IL-21R is broadly expressed on T, B and NK cells and, via the JAK-STAT pathway, transduces IL-21 signals that drive proliferation, differentiation and memory formation, thereby bridging innate and adaptive immunity. Clinically, hyper-activation of the IL-21/IL-21R axis promotes autoantibody production and is implicated in multiple autoimmune diseases, making this pathway a key biomarker and therapeutic target for autoantibody-mediated disorders.

  • 电泳

    • 2μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of IL-21 R His Tag Protein, Human is more than 95% determined by SEC-HPLC.

  • ELISA

    • Immobilized IL-21 Protein, Human (Cat. No. UA040009) at 1.0μg/mL (100μL/well) can bind IL-21 R His Tag Protein, Human (Cat. No. UA011349) with EC50 of 31.42-83.36 ng/mL.

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