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产品中心 药物靶点和Fc受体 药物靶点

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IFN-gamma R1/IFNGR1 Fc Chimera Protein, Human

CD119,CDw119,IFNGR,IFN-gamma-R1,IMD27A,IMD27B

价格 ￥950.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011347
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CD119,CDw119,IFNGR,IFN-gamma-R1,IMD27A,IMD27B

  • Accession

    P15260

  • 表达序列

    Glu18-Gly245 with hIgG1 Fc Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    60-72kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & > 90% SEC-HPLC

  • 活性

    Immobilized Human lFN-gamma, His Tag (Cat. No. S0A4003) at 5.0μg/mL (100μL/well) can bind IFN-gamma R1/IFNGR1 Fc Chimera Protein, Human (Cat. No. UA011347) with EC50 of 1.71-9.17ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Varol SE, Cinar C, Burtecene N, Sahin S, Yildiz M, Barut K, Cokugras H, Firtina S, Kasapcopur O, Kiykim A. Patients With IgA Vasculitis and Kawasaki Disease Show Dysregulated Interferon Signature. Int J Rheum Dis. 2025 Jul;28(7):e70349.
    2.Shepherd J, Jones J, Takeda A, Davidson P, Price A. Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation. Health Technol Assess. 2006 Aug;10(28):iii-iv, xi-xiv, 1-183.

背景介绍

  • CD119 (also known as IFNGR1) is the alpha-chain ligand-binding receptor for interferon-gamma, belonging to the type II cytokine receptor family. Its structure comprises two fibronectin type-III domains and two immunoglobulin-like C2-type domains. Together with IFNGR2, it forms a functional heterodimeric receptor, typically with two receptor molecules binding one IFNγ dimer. This receptor mediates signals from interferon-gamma produced by activated T lymphocytes, triggering antiviral activity, inhibition of cell proliferation, and broad immunoregulatory functions in various cell types. Deficiency in its function is associated with certain primary immunodeficiency disorders and holds significant clinical relevance in infection immunity, tumor immunity, and autoimmune diseases.

  • 电泳

    • 1μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of IFN-gamma R1/IFNGR1 Fc Chimera Protein, Human is more than 90% determined by SEC-HPLC.

  • ELISA

    • Immobilized Human lFN-gamma, His Tag (Cat. No. S0A4003) at 5.0μg/mL (100μL/well) can bind IFN-gamma R1/IFNGR1 Fc Chimera Protein, Human (Cat. No. UA011347) with EC50 of 1.71-9.17ng/mL.

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