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物种
Human分子别名
IL-2 receptor subunit gamma, IL2RGAccession
P31785-1表达序列
Leu23-Asn254 with hIgG1 Fc Tag at the C-Terminus
表达宿主
HEK293分子量
70-100kDa (Reducing)
纯度
＞95% by SDS-PAGE&HPLC标记
Unconjugated性状
Lyophilized Powder缓冲体系
PBS, pH7.4, 5% trehalose
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Kim JY, Mayatepek E, Seyfarth J, Jacobsen M. High common-γ cytokine receptor levels promote expression of Interleukin-2/Interleukin-7 receptor α-chains with implications on T-cell differentiation and function. Immunology. 2024 Sep;173(1):93-105.
2.Andreu-Ballester JC, Hurtado-Marcos C, García-Ballesteros C, Pérez-Griera J, Izquierdo F, Ollero D, Jiménez A, Gil-Borrás R, Llombart-Cussac A, López-Chuliá F, Cuéllar C. Decreased gene expression of interleukin 2 receptor subunit γ (CD132) in tissues of patients with Crohn's disease. World J Gastroenterol. 2025 Mar 28;31(12):97120.
3.Montorfani J, Hatterer E, Chatel L, Lesnier A, Viandier A, Daubeuf B, Nouveau L, Malinge P, Calloud S, Masternak K, Ferlin W, Fischer N, Jandus C, Shang L. Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies. J Immunother Cancer. 2025 Mar 25;13(3):e010650.
IL-2 Rγ/CD132 is a transmembrane protein belonging to the type I cytokine receptor family, characterized by a highly conserved extracellular WSXWS motif, a transmembrane region, and an intracellular domain containing Box1/Box2 motifs. It serves as the shared signaling chain for six cytokines: IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Through its intracellular domain, it couples with signaling molecules such as JAK3 and STAT5, playing an indispensable core role in T/NK cell development, lymphocyte homeostasis, and immune regulation. The clinical significance of this molecule is substantial—mutations in its gene cause X-linked severe combined immunodeficiency (X-SCID). Therapeutic strategies targeting this molecule have been translated in three key ways: gene therapy encoding γc (e.g., Strimvelis) has received clinical approval; CD132-targeting bispecific antibodies selectively activate the common receptor complex within the tumor microenvironment to achieve anti-tumor immunity while avoiding systemic toxicity; and engineered IL-2/antibody biased complexes modulate CD132-dependent signaling preferences to expand regulatory T cells for transplant tolerance and autoimmune disease treatment.
电泳
2μg (R: reducing condition, N:non-reducing condition).
体积排阻色谱(SEC-HPLC)
The purity of IL-2 Rγ/CD132 Fc Chimera Protein, Human is more than 95% determined by SEC-HPLC.
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