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产品中心 药物靶点和Fc受体 药物靶点

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MIS RII mFc Chimera Protein, Human

MIS RII,MRII,AMHR2,AMHR,MISR2,AMH type II receptor

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011292
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    MIS RII,MRII,AMHR2,AMHR,MISR2,AMH type II receptor

  • Accession

    Q16671-1

  • 表达序列

    Pro18-Ser144 with Mouse IgG2a Fc Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    48-60kDa (Reducing)

  • 纯度

    ＞90% by SDS-PAGE

  • 活性

  • 标记

    Unconjugated

  • 标签

    Mouse IgG2a Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Zhao J, Feng B, Zheng MH, Xu K. Surgical robots for SPL and NOTES: a review. Minim Invasive Ther Allied Technol. 2015 Feb;24(1):8-17.
    Mohri Y, Shimizu M, Fujimoto T, Nishikawa Y, Ikeda A, Matsuda Y, Wada T, 2.Kawaguchi C. A young child with pediatric multisystem inflammatory syndrome successfully treated with high-dose immunoglobulin therapy. IDCases. 2022 Mar 31;28:e01493.

背景介绍

  • MIS RII (Mullerian inhibiting substance type II receptor), also known as AMHRII (anti-Mullerian hormone type II receptor), is a serine/threonine receptor with a single transmembrane domain that belongs to the family of type II receptors of the TGF-beta superfamily. Mutations in MIS RII result in persistent Mullerian duct syndrome (PMDS), persistent Müllerian duct syndrome (PMDS) is a sex-limited disorder in which males develop portions of the female reproductive tract. Anti-Müllerian hormone (AMH) and its receptor (AMHR2) induce the regression of the Müllerian ducts in male embryos, but the mechanism by which the Amhr2 gene is specifically activated is not fully understood.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

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