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产品中心 药物靶点和Fc受体 CAR-T荧光标记靶点蛋白

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FITC-Labeled ROR1 Fc Chimera Protein, Human

NTRKR1,ROR1,Receptor Tyrosine Kinase Like Orphan Receptor 1,Neurotrophic Tyrosine Kinase,Receptor-Related 1

价格 ￥2,320.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011270
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    NTRKR1, ROR1, Receptor Tyrosine Kinase Like Orphan Receptor 1, Neurotrophic Tyrosine Kinase, Receptor-Related 1

  • Accession

    Q01973-1

  • 表达序列

    Gln30-Glu403 with Human IgG1 Fc at C-terminal

  • 表达宿主

    HEK293

  • 分子量

    85-95kDa(Reducing)

  • 标记

    FITC

  • 标签

    Human IgG1 Fc

  • 性状

    Liquid

  • 缓冲体系

    PBS, pH7.4

  • 储存条件

    · 12 months from date of receipt stored at --20 to -80℃.

    · 1 week, 2 to 8℃ under sterile conditions

    · Recommend to aliquot the protein into smaller quantities for optimal storage.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Quezada M J. et al. (2023) The signaling pathways activated by ROR1 in cancer. Cell Signal. 104: 110588.

背景介绍

  • The receptor tyrosine kinase orphan receptor 1 (ROR1) is a receptor for WNT5A and related Wnt proteins, that play an important role during embryonic development by regulating cell migration, cell polarity, neural patterning, and organogenesis. ROR1 exerts these functions by transducing signals from the Wnt secreted glycoproteins to the intracellular Wnt/PCP and Wnt/Ca++ pathways. Investigations in adult human cells, particularly cancer cells, have demonstrated that besides these two pathways, the WNT5A/ROR1 axis can activate a number of signaling pathways, including the PI3K/AKT, MAPK, NF-κB, STAT3, and Hippo pathways. Moreover, ROR1 is aberrantly expressed in cancer and was associated with tumor progression and poor survival by promoting cell proliferation, survival, invasion, epithelial to mesenchymal transition, and metastasis. Consequently, numerous therapeutic tools to target ROR1 are currently being evaluated in cancer patients.

注意事项

  • 请严格按照推荐用量进行实验，分群不明显情况下，可适当提高2-5倍推荐用量。

  • 流式分析

    • 2e5 of transient transfected anti- ROR1 ScFv CAR-293 cells were stained with 0.1ug FITC-Labeled ROR1 Fc Chimera Protein, Human, (Cat. No. UA011270) and unlable respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). FITC signal was used to evaluate the binding activity.
      2e5 of transient transfected anti- ROR1 ScFv CAR-293 cells were stained with isotype and Whitlow/218 Linker-Alexa Fluor® 488 (Fig. D and E). Alexa Fluor® 488 signal was used to evaluate the binding activity.

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