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产品中心 药物靶点和Fc受体 药物靶点

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IL-6R alpha/CD126 Fc Chimera Protein, Mouse

IL6R,IL-6R-1,IL-6RA,IL6RA,IL6RQ,gp80

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011252
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    IL6R, IL-6R-1, IL-6RA, IL6RA, IL6RQ, gp80

  • 表达序列

    Leu20-Glu357 with hIgG1 Fc at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    80-95 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE, >90% by SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized IL-6 Protein, Mouse (Cat. No. UA040155) at 2.0μg/mL (100μL/well) can bind IL-6R alpha/CD126 Fc Chimera Protein, Mouse (Cat. No.UA011252) with EC50 of 4.66-7.37ng/mL.

  • 标记

    Unconjugated

  • 标签

    Huamn IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS PH7.4 5% trehalose

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
    Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.

背景介绍

  • The IL-6 receptor (IL-6R/CD126) is a type-I cytokine receptor formed by an 80 kDa ligand-binding subunit (IL-6Rα) and a 130 kDa signal-transducing subunit (gp130). gp130 is ubiquitous, whereas IL-6Rα is confined mainly to hepatocytes and immune cells. IL-6 signaling occurs via two routes: classical signaling through membrane-bound IL-6Rα and trans-signaling mediated by soluble IL-6R (sIL-6R) generated through proteolytic cleavage or alternative splicing; sIL-6R enables IL-6 to activate gp130 on cells that lack membrane IL-6Rα, thereby broadening its biological impact. Dysregulation of this pathway drives chronic inflammation (e.g., rheumatoid arthritis, Crohn’s disease) and promotes malignancies such as multiple myeloma, making the receptor a validated therapeutic target—anti-IL-6R antibodies have shown clinical efficacy. The extracellular region of IL-6Rα contains conserved Ig-like and fibronectin type-III domains bearing the WSXWS motif, underscoring its functional importance across species despite minor species-specific processing differences.

  • 电泳

    • 2μg (R: reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of IL-6R alpha/CD126 Fc Chimera Protein, Mouse is greater than 90% as determined by SEC-HPLC.

  • ELISA

    • Immobilized IL-6 Protein, Mouse (Cat. No. UA040155) at 2.0μg/mL (100μL/well) can bind IL-6R alpha/CD126 Fc Chimera Protein, Mouse (Cat. No.UA011252) with EC50 of 4.66-7.37ng/mL.

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