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产品中心 药物靶点和Fc受体 药物靶点

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FGF-R2(IIIb) Fc Chimera Protein, Human

FGF R2 (IIIb),FGFR2B,FGFR2,Fibroblast growth factor receptor 2,FGFR-2,KSAM,KGFR,CD332,BEK

价格 ￥1,400.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011251
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    FGF R2 (IIIb), FGFR2B, FGFR2, Fibroblast growth factor receptor 2, FGFR-2, KSAM, KGFR, CD332, BEK

  • Accession

    P21802

  • 表达序列

    Arg22-Glu378 with hIgG1 Fc at C-terminus

  • 表达宿主

    HEK293

  • 分子量

    80-95 kDa(Reducing)

  • 纯度

    >95% by SDS-PAGE & >90% by SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized FGF-basic(146aa) Protein, Human (Cat. No. UA040145) at 2.0μg/mL (100μL/well) can bind FGF R2 (IIIb) Fc Chimera Protein, Human with EC50 of 11.71-28.91ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS PH7.4 5% trehalose

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Asada N, Tanaka Y, Hayashido Y, Toratani S, Kan M, Kitamoto M, Nakanishi T, Kajiyama G, Chayama K, Okamoto T. Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines. In Vitro Cell Dev Biol Anim. 2003 Jul-Aug;39(7):321-8.
    Carstens RP, Wagner EJ, Garcia-Blanco MA. An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. Mol Cell Biol. 2000 Oct;20(19):7388-400.

背景介绍

  • FGFR2 is a cell-surface tyrosine-kinase receptor for fibroblast growth factors that governs proliferation, differentiation, migration, and apoptosis during embryonic patterning, limb and lung morphogenesis, osteogenesis, and skin development. In osteoblasts, it differentially promotes proliferation/apoptosis depending on maturation stage. Ligand-activated FGFR2 phosphorylates PLCG1, FRS2, and PAK4, triggering PLCγ–DAG/IP3 and GRB2/GAB1/PI3K/SOS1–RAS/MAPK/AKT cascades. Signaling is attenuated by ubiquitination-mediated internalization and degradation; mutations causing constitutive activation or impaired trafficking yield aberrant signaling, while overexpression enhances STAT1 activation.

  • 电泳

    • 2μg (R: reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of FGF R2 (IIIb) Fc Chimera Protein, Human is greater than 90% as determined by SEC-HPLC.

  • ELISA

    • Immobilized FGF-basic(146aa) Protein, Human (Cat. No. UA040145) at 2.0μg/mL (100μL/well) can bind FGF R2 (IIIb) Fc Chimera Protein, Human with EC50 of 11.71-28.91ng/mL.

    • Immobilized FGF-10 Protein, Rat (Cat. No. UA040262) at 5μg/mL (100μL/well) can bind FGF-R2(IIIb) Fc Chimera Protein, Human (Cat. No. UA011251) with EC50 of 14.19-30.85 ng/mL.

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