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物种
Human分子别名
ADPRC1,cADPR1,ADPRC 1Accession
P28907-1表达序列
Val43-Ile300 with Human IgG1 Fc at C-terminal
表达宿主
HEK293分子量
68-72kDa (Reducing)
标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, pH7.4
储存条件
· 12 months from date of receipt stored at --20 to -80℃.
· 1 week, 2 to 8℃ under sterile conditions
· Recommend to aliquot the protein into smaller quantities for optimal storage.
· Please avoid repeated freeze-thaw cycles.
文献引用
1.Matas-Céspedes A, Vidal-Crespo A, Rodriguez V, Villamor N, Delgado J, Giné E, Roca-Ho H, Menéndez P, Campo E, López-Guillermo A, Colomer D, Roué G, Wiestner A, Parren PW, Doshi P, van Bueren JL, Pérez-Galán P. The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 Mar 15;23(6):1493-1505.
2.Lokhorst HM, Plesner T, Laubach JP, Nahi H, Gimsing P, Hansson M, Minnema MC, Lassen U, Krejcik J, Palumbo A, van de Donk NW, Ahmadi T, Khan I, Uhlar CM, Wang J, Sasser AK, Losic N, Lisby S, Basse L, Brun N, Richardson PG. Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma. N Engl J Med. 2015 Sep 24;373(13):1207-19.
Daratumumab is a first-in-class Homo sapiens monoclonal antibody of the IgG1 class, specifically targeting the human CD38 protein. It binds to CD38, triggering apoptosis via mechanisms of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). This antibody is applicable for research related to hematoma, suitable for use in both human and immunodeficient mouse models. Studies have indicated that Daratumumab also exerts influence on the survivability and transmission of chronic lymphocytic leukemia (CLL), particularly in cases characterized by poor prognosis and high CD38 expression.
流式分析
2e5 of transient transfected anti-CD38 ScFv CAR-293 cells were stained with 0.01ug Alexa Fluor 647-Labeled CD38 Fc Chimera Protein, Human, (Cat. No. UA011239) and unlable respectively (Fig. C and B), and non-transfected 293 cells were used as a control (Fig. A). Alexa Fluor 647 signal was used to evaluate the binding activity.
2e5 of transient transfected anti- CD38 ScFv CAR-293 cells were stained with 0.01ug CD38 Fc Chimera Protein, Human (Cat. No. UA010182) (Fig. D). 2e5 of transient transfected anti- CD38 ScFv CAR-293 cells were stained with isotype and Whitlow/218 Linker-Alexa Fluor® 488 (Fig. E and F). Alexa Fluor® 488 signal was used to evaluate the binding activity.
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