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Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human

ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2

货号： UA011204

Datasheet COA
  • 价格： ￥1,200
  • 规格：
  • 数量：
斯达特大包装询价 大包装询价

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    ANGPTL3,ANGPT5,ANG-5,Angiopoietin-5,FHBL2

  • Accession

    Q9Y5C1-1

  • 表达序列

    Ser17-Glu460 with His Tag at the C-terminus

  • 表达宿主

    HEK293

  • 分子量

    60-75 kDa (Reducing)

  • 纯度

    > 95 % as determined by SDS-PAGE & RP-HPLC; > 90 % as determined by SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human (Cat. No. UA011204) at 2.0μg/mL (100μL/well) can bind ANGPTL3 Recombinant Rabbit mAb (SDT-425-59) (Cat. No. S0B3204) with EC50 of 0.96-1.35ng/mL.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4,5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Arch Esp Urol. 2025 Jan;78(1):84-92.
    World J Gastrointest Oncol. 2025 Feb 15;17(2):97858.

  • 稀释度

背景介绍

  • ANGPTL3, also known as angiopoietin-related protein 3 or angiopoietin-5 (ANGPT5), is a secreted factor in the angiopoietin-like family. Predominantly expressed in the liver, it features a signal peptide, an N-terminal coiled-coil domain, and a C-terminal fibrinogen-like domain. The fibrinogen-like domain binds alpha-5/beta-3 integrins, promoting endothelial cell adhesion and migration, and may regulate angiogenesis. ANGPTL3 also inhibits lipoprotein lipase and endothelial lipase, increasing plasma triglycerides and HDL cholesterol in rodents. By blocking endothelial lipase, it raises HDL-phospholipid levels, enhancing cholesterol efflux.

  • 电泳

    • 1μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human is more than 90% determined by SEC-HPLC.

  • ELISA

    • Immobilized Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human (Cat. No. UA011204) at 2.0μg/mL (100μL/well) can bind ANGPTL3 Recombinant Rabbit mAb (SDT-425-59) (Cat. No. S0B3204) with EC50 of 0.96-1.35ng/mL.

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