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产品中心 药物靶点和Fc受体 药物靶点

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CD40 Fc&His Tag Protein, Human

Bp50,CD40 Antigens,CD40,B Cell Surface Antigen CD40,B-Cell Surface Antigen CD40,CDW40,CD40L Receptor,CD40 Molecule,Tumor Necrosis Factor Receptor Superfamily,Member 5,TNF Receptor Superfamily Member 5,TNFRSF5,Tumor Necrosis Factor Receptor Superfamily Member 5,P50,CD40 Antigen,B Cell-Associated Molecule

价格 ￥990.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011202
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Bp50，CD40 Antigens，CD40，B Cell Surface Antigen CD40，B-Cell Surface Antigen CD40，CDW40，CD40L Receptor，CD40 Molecule，Tumor Necrosis Factor Receptor Superfamily， Member 5，CD40 Molecule， TNF Receptor Superfamily Member 5，TNFRSF5，Tumor Necrosis Factor Receptor Superfamily Member 5，P50，CD40 Antigen，B Cell-Associated Molecule

  • Accession

    P25942

  • 表达序列

    Glu21-Arg193 with Fc&His Tag at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    50-60kDa (Reducing)

  • 纯度

    > 95 % as determined by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    1.Immobilized Biotinylated Human CD40L/CD154/TRAP/gp39 Protein, His&Avi tag (Cat. No. S0A1141) at 2μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind CD40 Fc&His Tag, Human (Cat. No. UA011202) with EC50 of 8.97-16.18ng/ml. 2.Immobilized Human CD40 Ligand/TNFSF5 protein, His tag (Cat. No. S0A1123) at 5.0μg/mL (100μL/well) can bind CD40 Fc&His Tag, Human (Cat. No. UA011202) with EC50 of 0.12-0.19ug/mL.

  • 标记

    Unconjugated

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Hanlon MM, Smith CM, Canavan M, Neto NGB, Song Q, Lewis MJ, O'Rourke AM, Tynan O, Barker BE, Gallagher P, Mullan R, Hurson C, Moran B, Monaghan MG, Pitzalis C, Fletcher JM, Nagpal S, Veale DJ, Fearon U. Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset. Sci Adv. 2024 Sep 27;10(39):eadj1252.

背景介绍

  • CD40, a member of the TNF receptor superfamily, is a glycoprotein crucial for immune responses. It's key for T cell-dependent processes like immunoglobulin class switching, memory B cell development, and germinal center formation. Expressed on B cells, dendritic cells, macrophages, and some tumor cells, CD40 interacts with CD40L to initiate signaling pathways. This interaction is vital for humoral immunity. CD40 defects can lead to hyper-IgM immunodeficiency type 3 (HIGM3), causing issues in B cell isotype switching and antibody responses. CD40's extracellular domain has cysteine-rich repeats, typical of TNF receptors. Early studies emphasized its role in humoral immunity.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of CD40 Fc&His Tag Protein, Human is greater than 95% as determined by SEC-HPLC.

  • ELISA

    • Immobilized Biotinylated Human CD40L/CD154/TRAP/gp39 Protein, His&Avi tag (Cat. No. S0A1141) at 2μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind CD40 Fc&His Tag, Human (Cat. No. UA011202) with EC50 of 8.97-16.18ng/ml.

    • Immobilized Human CD40 Ligand/TNFSF5 protein, His tag (Cat. No. S0A1123) at 5.0μg/mL (100μL/well) can bind CD40 Fc&His Tag, Human (Cat. No. UA011202) with EC50 of 0.12-0.19ug/mL.

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