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产品中心 药物靶点和Fc受体 药物靶点

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IFN-alpha/beta R1 Fc Chimera Protein, Human

IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1

价格 ￥1,100.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011186
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1

  • Accession

    P17181-1

  • 表达序列

    Target (Lys28-Lys436) with hIgG1 Fc at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    90-120 KDa(Reducing)

  • 纯度

    ＞95% by SDS-PAGE &＞90% by SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    1.Protein A Chip captured IFN-alpha/beta R1 Fc Chimera Protein, Human (Cat. No. UA011186), can bind IFN-α 2a Protein, Human (Cat. No. UA040038) with an affinity constant of 1.30μM as determined in SPR assay. 2.Protein A Chip captured IFN-alpha/beta R1 Fc Chimera Protein, Human (Cat. No. UA011186), can bind Human IFN-α2, His Tag (Cat. No. S0A4005) with an affinity constant of 1.52μM as determined in SPR assay.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 缓冲体系

    PBS PH7.4 5% trehalose

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Jacob RA, Zhang A, Ajoge HO, D'Agostino MR, Nirmalarajah K, Shigayeva A, Demian WL, Baker SJC, Derakhshani H, Rossi L, Nasir JA, Panousis EM, Draia AN, Vermeiren C, Gilchrist J, Smieja N, Bulir D, Smieja M, Surette MG, McArthur AG, McGeer AJ, Mubareka S, Banerjee A, Miller MS, Mossman K. Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada. Emerg Infect Dis. 2023 Jul;29(7):1386-1396.

背景介绍

  • Interferon alpha/beta receptor 1 (IFNAR1), also known as Cytokine receptor class-II member 1 (CRF2-1) or Type I interferon receptor 1, belongs to the type II cytokine receptor family. It contains four fibronectin type-III domains and pairs with IFNAR2 to form the type I interferon receptor. IFNAR1 serves as the receptor for interferons alpha and beta. Notably, IFNAR1 can transduce IFNβ signals independently of IFNAR2, without activating the Jak-STAT pathway.

  • 电泳

    • 1μg (R: reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of IFN-alpha/beta R1 Fc Chimera Protein, Human is greater than 90% as determined by SEC-HPLC.

  • SPR

    • Protein A Chip captured IFN-alpha/beta R1 Fc Chimera Protein, Human (Cat. No. UA011186), can bind IFN-α 2a Protein, Human (Cat. No. UA040038) with an affinity constant of 1.30μM as determined in SPR assay.

    • Protein A Chip captured IFN-alpha/beta R1 Fc Chimera Protein, Human (Cat. No. UA011186), can bind Human IFN-α2, His Tag (Cat. No. S0A4005) with an affinity constant of 1.52μM as determined in SPR assay.

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