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产品中心 药物靶点和Fc受体 药物靶点

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BTN1A1/Butyrophilin Fc Chimera Protein, Human

BTN,BT,BTN1

价格 ￥1,100.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011184
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    BTN,BT,BTN1

  • Accession

    Q13410-1

  • 表达序列

    Ala27-Arg242 with hIgG1 Fc Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    55-70kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & > 95% SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Chen B, Li K, Wang X, Zhang W, Han S, Zhang Y, Wang Y, Pang X, Xie Q, Lu J, Jiang S, Zhang S, Lv J. Dynamic Variations in Endogenous Peptides in Chinese Human Milk Across Lactation and Geographical Regions. Nutrients. 2025 Sep 30;17(19):3131.
    2.Xie M, Yuan W, Tian Z, Tan L, Zhou H, Yang Q, Zhou L, Shan W, Luo J, Fan X. Advances in isolation, composition, properties and applications of milk fat globule membrane proteins: A review. Food Res Int. 2025 Dec;221(Pt 3):117422.

背景介绍

  • BTN1A1 (also known as butyrophilin subfamily 1 member A1) is a 55 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. Its structure includes extracellular IgV/IgC domains, a transmembrane region, and a cytoplasmic tail containing a B30.2 domain. Functionally, the B30.2 domain binds to xanthine oxidoreductase (XOR) to regulate milk fat globule secretion, while also serving as an intracellular phosphoantigen sensor to activate γδ T cells. Additionally, BTN1A1 inhibits CD4+ T cell proliferation, reduces the secretion of cytokines such as IL-2 and IFN-γ, and demonstrates protective effects in experimental autoimmune encephalomyelitis (EAE) models. Given its structural similarity to the B7 family and its involvement in immune regulation, BTN1A1 represents a potential novel co-stimulatory/inhibitory molecule and a promising therapeutic target for autoimmune and immune-related diseases.

  • 电泳

    • 1μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of BTN1A1/Butyrophilin Fc Chimera Protein, Human is more than 95% determined by SEC-HPLC.

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