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产品中心 药物靶点和Fc受体 药物靶点

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IFNAR1 Fc Chimera Protein, Human

IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1

价格 ￥1,100.00 （ 1-2周）
货号 UA011167
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    IFNAR1, IFNAR, CRF2-1, IFN-R-1, IFNAR-1

  • Accession

    P17181-1

  • 表达序列

    Lys28-Lys436, with Human IgG1 Fc at the C-terminal

  • 表达宿主

    HEK293

  • 分子量

    95-125kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & ＞85% by SEC-HPLC

  • 活性

    Protein A Chip captured IFNAR1 Fc Chimera Protein, Human (Cat. No. UA011167), can bind Human IFN-alpha1, His tag (Cat. No. S0A4013) with an affinity constant of 0.30μM as determined in SPR assay.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Jacob RA, Zhang A, Ajoge HO, D'Agostino MR, Nirmalarajah K, Shigayeva A, Demian WL, Baker SJC, Derakhshani H, Rossi L, Nasir JA, Panousis EM, Draia AN, Vermeiren C, Gilchrist J, Smieja N, Bulir D, Smieja M, Surette MG, McArthur AG, McGeer AJ, Mubareka S, Banerjee A, Miller MS, Mossman K. Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada. Emerg Infect Dis. 2023 Jul;29(7):1386-1396.

背景介绍

  • Interferon alpha/beta receptor 1 (IFNAR1), also known as Cytokine receptor class II member 1 (CRF2-1) or Type I interferon receptor 1, is a member of the type II cytokine receptor family. IFNAR1 contains four fibronectin type-III domains and forms the type I interferon receptor when associated with IFNAR2. As a receptor for interferons alpha and beta, IFNAR1 can transduce IFNβ signals independently of IFNAR2, although this does not activate the Jak-STAT pathway.

  • 电泳

  • 体积排阻色谱(SEC-HPLC)

  • SPR

    • Protein A Chip captured IFNAR1 Fc Chimera Protein, Human (Cat. No. UA011167), can bind Human IFN-alpha1, His tag (Cat. No. S0A4013) with an affinity constant of 0.30μM as determined in SPR assay.

    • Protein A Chip captured IFNAR1 Fc Chimera Protein, Human (Cat. No. UA011167), can bind IFN-Omega Protein, Human (Cat. No. UA040381) with an affinity constant of 154 nM as determined in SPR assay.

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