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产品中心 药物靶点和Fc受体 药物靶点

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HMGB1/HMG1 His Tag Protein, Mouse

High mobility group protein 1 (HMG-1),Hmgb1,Hmg-1,Hmg1,HMG3,SBP-1

价格 ￥1,580.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011157
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    High mobility group protein 1 (HMG-1); Hmgb1; Hmg-1; Hmg1; HMG3, SBP-1

  • Accession

    P63158

  • 表达序列

    Met1-Glu215 with His tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    30-35kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & ＞90% by SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Ulloa L, et al. (2006) High-mobility group box 1 (HMGB1) protein: friend and foe. Cytokine Growth Factor Rev. 17 (3): 189-201.
    2.Pisetsky DS, et al. (2008) High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther. 10 (3): 209.
    3.Volz HC, et al. (2010) The role of HMGB1/RAGE in inflammatory cardiomyopathy. Semin Thromb Hemost. 36(2): 185-94.
    4.Sims GP, et al. (2010) HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 28: 367-88.
    5.Andersson U, et al. (2010) The role of HMGB1 in the pathogenesis of rheumatic disease. Biochim Biophys Acta. 1799 (1-2): 141-8.

背景介绍

  • High-mobility group protein B1 (HMGB1), also referred to as high-mobility group protein 1 (HMG-1) or amphoterin, is a member of the HMGB family, which includes HMGB1, HMGB2, and HMGB3. HMGB1 is a non-histone architectural chromosomal protein found in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. It plays a role in the mechanisms of inflammation and damage by binding to TLR4, thereby mediating HMGB1-dependent activation of macrophage cytokine release. This places HMGB1 at the crossroads of sterile and infectious inflammatory responses. Studies have explored HMGB1 as an adjuvant for DNA vaccines and as a potential target for cancer therapy.

  • 电泳

    • 1μg (R: reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of HMGB1/HMG1 His Tag Protein, Mouse is more than 90% determined by SEC-HPLC.

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