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产品中心 药物靶点和Fc受体 药物靶点

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NOTCH3 Fc Chimera Protein, Human

CADASIL,CASILneurogenic locus notch homolog protein 3,Notch (Drosophila) homolog 3,notch 3Notch homolog 3 (Drosophila),Notch homolog 3,Notch3,Notch-3

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011148
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3

  • Accession

    Q9UM47

  • 表达序列

    Ala40 - Glu467 with Human IgG1 Fc at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    75-90kDa (Reducing)

  • 内毒素含量

    <0.1EU/μg

  • 活性

    ＞95% by SDS-PAGE & SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

背景介绍

  • Notch3 is one of the four mammalian Notch proteins that serve as signaling receptors and are involved in developmental patterning, cell fate decisions, and the regulation of cell survival and proliferation. Notch3 interacts with membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell fate determination. Upon ligand activation, the Notch intracellular domain (NICD) is released and forms a transcriptional activator complex with RBPJ/RBPSUH, which in turn activates genes within the enhancer of split locus. As a result, the activation of Notch3 can initiate differentiation, proliferation, and apoptotic programs.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of NOTCH3 Fc Chimera Protein, Human is more than 95% as determined by SEC-HPLC.

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