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产品中心 药物靶点和Fc受体 药物靶点

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SIRP alphaV2/CD172a His Tag Protein, Human

SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011147
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    SHPS1, SIRPA, CD172A, BIT, MFR, MYD1, P84, PTPNS1

  • Accession

    ATD50864.1

  • 表达序列

    Glu31-Arg369 with His Tag at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    47-60kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 活性

    Immobilized SIRP alphaV2/CD172a His Tag Protein, Human (Cat. No. UA011147) at 2.0μg/mL (100μL/well) can bind CD47 Fc Chimera Protein, Human (Cat. No. UA010006) with EC50 of 1.98-2.64 ng/mL.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Tanaka Y, Hu Q, Kawazoe T, Tajiri H, Nakanishi R, Zaitsu Y, Nakashima Y, Ota M, Oki E, Oda Y, Yoshizumi T. The clinical significance of signal regulatory protein alpha expression in the immune environment of gastric cancer. Int J Clin Oncol. 2024 Nov 26.
    Shao C, Tang B, Chu JCH, Lau KM, Wong WT, Che CM, Tai WCS, Wong WT, Wong CTT. Macrophage-engaging peptidic bispecific antibodies (pBsAbs) for immunotherapy via a facile bioconjugation strategy. Chem Sci. 2024 Apr 30;15(29):11272-11278.

背景介绍

  • Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1), also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha), or p84, is a member of the SIRP family and belongs to the immunoglobulin superfamily. SIRP alpha is ubiquitously expressed, with particularly high levels in the brain. SIRPA/CD172a is an immunoglobulin-like cell surface receptor for CD47 and functions as a docking protein, facilitating the translocation of PTPN6, PTPN11, and other binding partners from the cytosol to the plasma membrane. SIRPA/SHPS-1 supports the adhesion of cerebellar neurons, neurite outgrowth, and glial cell attachment, and may play a key role in intracellular signaling during synaptogenesis and synaptic function.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Immobilized SIRP alphaV2/CD172a His Tag Protein, Human (Cat. No. UA011147) at 2.0μg/mL (100μL/well) can bind CD47 Fc Chimera Protein, Human (Cat. No. UA010006) with EC50 of 1.98-2.64 ng/mL.

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