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产品中心 药物靶点和Fc受体 药物靶点

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LDLR His Tag Protein, Cynomolgus

FH,FHC,LDLCQ2

价格 ￥1,480.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011139
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus

  • 分子别名

    FH, FHC, LDLCQ2

  • Accession

    XP_005588053.2

  • 表达序列

    Ala22-Gly788 with His tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    120-140kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Canbay E, Canda E, Yazıcı H, Kasıkcı GK, Durmaz B, Copur O, Tahhan B, Düzgün D, Koru ZE, Sezer E, Aydın D, Levent RE, Ucar SK, Coker M, Sozmen EY. Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia. Lipids Health Dis. 2024 Nov 13;23(1):374.

背景介绍

  • The Low-Density Lipoprotein (LDL) Receptor, also known as LDLR, FH, FHC, or LDLCQ2, is a mosaic protein composed of approximately 840 amino acids (after signal peptide removal) that mediates the endocytosis of cholesterol-rich LDL. This cell-surface receptor recognizes apolipoprotein B100, which is embedded in the phospholipid outer layer of LDL particles, as well as apolipoprotein E found in chylomicron remnants and VLDL remnants (IDL). The LDL receptor belongs to the LDL receptor gene family.
    LDL receptor complexes are located in clathrin-coated pits on the cell surface. When bound to LDL-cholesterol via adaptors, these complexes are internalized to form clathrin-coated vesicles within the cell. This process, known as endocytosis, allows for the efficient internalization of LDL-cholesterol and prevents it from diffusing across the membrane surface. This occurs in all nucleated cells, but is most prominent in the liver, which removes approximately 70% of LDL from the circulation.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of LDLR His Tag Protein, Cynomolgus is more than 95% determined by SEC-HPLC.

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