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ROBO1/DUTT1 His Tag Protein, Human

DUTT1,DUTT1Drosophila) homolog 1,H-Robo-1,MGC131599,MGC133277,ROBO1,roundabout,axon guidance receptor,homolog 1 (Drosophila)

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011135
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    DUTT1; DUTT1Drosophila) homolog 1; H-Robo-1; MGC131599; MGC133277; ROBO1; roundabout, axon guidance receptor, homolog 1 (Drosophila)

  • Accession

    NP_598334.2

  • 表达序列

    Ser34-Pro872 with His Tag at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    100-125kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Dudanova, I and R. Klein (2013) Trends Neurosci. 36:295.

背景介绍

  • ROBO1, a 170-200 kDa protein, is a member of the ROBO family of guidance molecules. It functions as a repulsive molecule that prevents axons from crossing the midline in the developing central nervous system (CNS). ROBO1 regulates the responsiveness to Netrin-1 and Semaphorin 3A and 3F by forming cis complexes with Neuropilin-1, Neuropilin-2, Plexin A1, DCC, and FLRT3.
    Additionally, ROBO1 is expressed in developing ductal epithelia, where its binding to Slit2 limits branching morphogenesis. The interaction between ROBO1 and Slit2 can also suppress tumorigenesis, enhance VEGF-induced angiogenesis, and enhance CXCL12-induced T cell chemotaxis by associating with CXCR4.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of ROBO1/DUTT1 His Tag Protein, Human is greater than 95% as determined by SEC-HPLC.

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