CXADR Fc Chimera Protein, Mouse
CAR10Coxsackievirus B-adenovirus receptor,CAR4/6,coxsackie virus and adenovirus receptor,coxsackie virus B receptor,coxsackievirus and adenovirus receptor,CVB3 binding protein,CVB3 BP,CVB3-binding protein,CXADR,HCAR,HCVADR
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物种
Mouse分子别名
CAR10Coxsackievirus B-adenovirus receptor; CAR4/6; coxsackie virus and adenovirus receptor; coxsackie virus B receptor; coxsackievirus and adenovirus receptor; CVB3 binding protein; CVB3 BP; CVB3-binding protein; CXADR; HCAR; HCVADRAccession
P97792表达序列
Leu20-Gly237 with Human IgG1 Fc at C-Terminus表达宿主
HEK293分子量
55-70kDa (Reducing)
纯度
＞95% by SDS-PAGE & SEC-HPLC内毒素含量
<0.1EU/μg标记
Unconjugated标签
Human IgG1 Fc性状
Lyophilized Powder缓冲体系
PBS, PH7.4, 5% trehalose溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Philipson, L. et al., 2004, Curr. Top. Microbiol. Immunol. 273:87-111.
2.Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-1580.
CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family within the immunoglobulin (Ig) superfamily. It plays a crucial role in normal cardiac development in mice. CXADR is proposed to function as a homophilic cell adhesion molecule and is a component of the epithelial apical junction complex, which is essential for maintaining tight junction integrity. It is also likely involved in the transepithelial migration of polymorphonuclear leukocytes (PMNs).
The mature mouse CXADR structure comprises a 218 amino acid (aa) extracellular domain (ECD), which includes a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment, and a 17 aa intracellular domain. Notably, D1 is believed to be responsible for homodimer formation within tight junctions. The ECD of mouse CXADR shares 97% sequence identity with the corresponding regions of human CXADR and 9% sequence identity with those of rat CXADR.
电泳
1μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
The purity of CXADR Fc Chimera Protein, Mouse is greater than 95% as determined by SEC-HPLC.
ELISA
Immobilized Recombinant Mouse JAML/AMICA Protein (His Tag), HPLC-verified at 2.0μg/mL (100μL/well) can bind CXADR Fc Chimera Protein, Mouse (Cat. No. UA011124) with EC50 of 12.27-23.60 ng/mL.
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