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产品中心 药物靶点和Fc受体 药物靶点

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ZNRF3 Fc Chimera Protein, Human

ZNRF3,Zinc,RING finger protein 3,RING-type E3 ubiquitin transferase ZNRF3,RING finger protein 203,KIAA1133,RNF203

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011119
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    ZNRF3, Zinc, RING finger protein 3, RING-type E3 ubiquitin transferase ZNRF3, RING finger protein 203, KIAA1133, RNF203

  • Accession

    Q9ULT6-1

  • 表达序列

    Lys56-Met219 with Human IgG1 Fc at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    45-55kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE &＞90% by SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized RSPO3 His Tag, Human (Cat. No. UA040025) at 2.0μg/mL (100μL/well) can bind ZNRF3 Fc Chimera Protein, Human (Cat. No. UA011119) with EC50 of 1.59-3.16 ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.SwissProt Accession # Q9ULT6.

背景介绍

  • ZNRF3 (zinc/RING finger protein 3), also known as RNF203, is a predicted 101kDa type I transmembrane protein and a member of the ZNRF3 family of ubiquitin ligases. This protein is specifically expressed in stem cells located at the base of colon crypts, where it restricts the proliferative effects of Wnts proteins. ZNRF3 is also found in normal gastric tissues; however, its expression is downregulated in gastric adenocarcinomas.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of ZNRF3 Fc Chimera Protein, Human is greater than 90% as determined by SEC-HPLC.

  • ELISA

    • Immobilized RSPO3 His Tag, Human (Cat. No. UA040025) at 2.0μg/mL (100μL/well) can bind ZNRF3 Fc Chimera Protein, Human (Cat. No. UA011119) with EC50 of 1.59-3.16 ng/mL.

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