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产品中心 药物靶点和Fc受体 药物靶点

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LRRC15/LIB Fc Chimera Protein, Human

Leucine-rich repeat-containing protein 15,LRRC15,LIB,hLib

价格 ￥960.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011115
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Leucine-rich repeat-containing protein 15, LRRC15, LIB, hLib

  • Accession

    Q8TF66-1

  • 表达序列

    Tyr22-Gly538 with Human IgG1 Fc at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    95-105kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE &＞90% by SEC-HPLC

  • 活性

    Immobilized LRRC15/LIB Fc Chimera Protein, Human (Cat. No. UA011115) at 5.0μg/mL (100μL/well) can bind Biotinylated Samrotamab with EC50 of 4.51-6.99ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Nagy Á, Ulmert D, Zedan W, Storey CM, Park J, Geres S, Lückerath K, Sjöström K, Westin H, Peekhaus N, Thorek DL, Karlström AE, Altai M. Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics. Eur J Med Chem. 2024 Sep 30;280: 116927.

背景介绍

  • LRRC15, also known as LIB and hLib, is a leucine-rich repeat-containing protein that is highly expressed in various solid tumors. It is found on stromal fibroblasts in many solid tumors, including those of the breast, head and neck, lung, and pancreas, as well as directly on a subset of cancer cells of mesenchymal origin, such as sarcoma, melanoma, and glioblastoma. LRRC15 expression can be induced by TGFβ in activated fibroblasts (positive for α-smooth muscle actin, αSMA) and in mesenchymal stem cells. These collective findings suggest that LRRC15 serves as a novel cancer-associated fibroblast (CAF) and mesenchymal marker, making it a potential therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or those of mesenchymal origin.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of LRRC15/LIB Fc Chimera Protein, Human is more than 90% determined by SEC-HPLC.

  • ELISA

    • Immobilized LRRC15/LIB Fc Chimera Protein, Human (Cat. No. UA011115) at 5.0μg/mL (100μL/well) can bind Biotinylated Samrotamab with EC50 of 4.51-6.99ng/mL.

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