ENPP3/CD203c Fc Chimera Protein, Mouse
EC:3.1.4.1,E-NPP 3,PD-Ibeta,NPPase,CD203c,PDNP3,Phosphodiesterase I/nucleotide pyrophosphatase 3,Nucleotide diphosphatase,ENPP3,DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3),Phosphodiesterase-I Beta,Phosphodiesterase I Beta,CD203c Antigen,Gp130RB13-6,NPP3,B10,Ectonucleotide pyrophosphatase/phosphodiesterase family member 3,Ectonucleotide Pyrophosphatase/Phosphodiesterase 3,DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3),EC:3.6.1.9
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物种
Mouse分子别名
EC:3.1.4.1，E-NPP 3，PD-Ibeta，NPPase，CD203c，PDNP3，Phosphodiesterase I/nucleotide pyrophosphatase 3，Nucleotide diphosphatase，ENPP3，DJ914N13.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，Phosphodiesterase-I Beta，Phosphodiesterase I Beta，CD203c Antigen，Gp130RB13-6，NPP3，B10，Ectonucleotide pyrophosphatase/phosphodiesterase family member 3，Ectonucleotide Pyrophosphatase/Phosphodiesterase 3，DJ1005H11.3 (Phosphodiesterase I/Nucleotide Pyrophosphatase 3)，EC:3.6.1.9Accession
Q6DYE8表达序列
Arg46-Ile874 with Human IgG1 Fc Tag at N-Terminus表达宿主
HEK293分子量
110-150kDa (Reducing)纯度
＞95% by SDS-PAGE &＞90% by SEC-HPLC内毒素含量
<0.1EU/μg标记
Unconjugated标签
Human IgG1 Fc性状
Lyophilized Powder缓冲体系
PBS, PH7.4, 5% trehalose溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Yao, Wang, Han et al.[J] J Transl Med. (2023) 21 (1), 594.
ENPP3 (CD203c, ENPP3) is a member of the human NPP (Nucleotide Pyrophosphatase/Phosphodiesterase) family. It is expressed in various organs, including on epithelial and mucosal surfaces, and is particularly notable on basophils and mast cells. NPP3 serves as a common marker for diagnosing allergen sensitivity by analyzing patient basophils using flow cytometry.
Basophils and mast cells play a role in mediating responses to certain pathogens as well as acute and chronic allergic reactions. Upon activation, these cells release ATP, which further stimulates them in an autocrine manner. The upregulation of NPP3 helps to degrade ATP and suppresses chronic allergic inflammation, without affecting the acute response.
电泳
1μg (R: reducing condition).
体积排阻色谱(SEC-HPLC)
The purity of ENPP3/CD203c Fc Chimera Protein, Mouse is greater than 90% as determined by SEC-HPLC.
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