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物种
Mouse分子别名
ALPG, GCAP, ALP-1, ALPPL2, PLAP-like, ALPPL, Alkaline phosphatase, germ cell typeAccession
P24823表达序列
Val19-Ser502 with His Tag at C-Terminus表达宿主
HEK293分子量
60-72kDa (Reducing)纯度
＞95% by SDS-PAGE &＞85% by SEC-HPLC内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, PH7.4, 5% trehalose溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Yang Su, et al. ALPPL2 Is a Highly Specific and Targetable Tumor Cell Surface Antigen. Cancer Res, 2020.
Axel, et al. Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits. bioRxiv, 2021.
Shuang Liu, et al. High expression of ALPPL2 is associated with poor prognosis in gastric cancer, Human Pathology, 2019.
Pooja Dua, et al. Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein. Cancer Res 2013.
5. Bi, Yan, et al. Identification of ALPPL2 as a naive pluripotent state-specific surface protein essential for human naive pluripotency regulation. Cell Reports, 2020.
Alkaline phosphatase, placental-like 2 (ALPPL2, also known as ALPG) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein and a member of the human alkaline phosphatase family. Typically not expressed in normal tissues except for the trophoblast, ALPPL2 shows a high tumor specificity. Immunohistochemical (IHC) analysis of tumor tissue arrays has revealed its expression in 43% of mesotheliomas, 60% of ovarian cancers, 36% of pancreatic cancers, 18% of gastric cancers, and 100% of seminomas.
ALPPL2 is not only a candidate for therapy development targeting ALPPL2-expressing tumors but has also been identified as a significant surface marker specific to the naive state of pluripotency, which is essential for both the establishment and maintenance of this state. Studies have demonstrated that the knockout of ALPPL2 can specifically impact the establishment, stability, and maintenance of naive pluripotency, confirming that the ALPPL2 protein is a functional molecular marker of the naive state surface.
电泳
1μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
The purity of ALPG His Tag Protein, Mouse is greater than 85% as determined by SEC-HPLC.
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