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产品中心 药物靶点和Fc受体 药物靶点

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CXADR/CAR His Tag Protein, Mouse

Coxsackievirus and adenovirus receptor homolog,CAR,Cxadr,CVB3 BP

价格 ￥1,680.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011111
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    Coxsackievirus and adenovirus receptor homolog, CAR, Cxadr, CVB3 BP

  • Accession

    NP_001020363.1

  • 表达序列

    Ala2-Gly237 with His Tag at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    32-34kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Philipson, L. et al., 2004, Curr. Top. Microbiol. Immunol. 273:87-111.
    2.Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-1580.

背景介绍

  • CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein that belongs to the CTX family within the immunoglobulin (Ig) superfamily. It is crucial for normal cardiac development in mice. CXADR is proposed to function as a homophilic cell adhesion molecule and is a component of the epithelial apical junction complex, which is essential for maintaining tight junction integrity. It is also likely involved in the transepithelial migration of polymorphonuclear leukocytes (PMNs).
    The mature mouse CXADR structure consists of a 218 amino acid (aa) extracellular domain (ECD), which includes a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment, and a 17 aa intracellular domain. Notably, D1 is believed to be responsible for homodimer formation within tight junctions. The ECD of mouse CXADR shares 97% sequence identity with the corresponding regions of human CXADR and 9% sequence identity with those of rat CXADR.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of CXADR/CAR His Tag Protein, Mouse is more than 95% determined by SEC-HPLC.

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