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产品中心 药物靶点和Fc受体 药物靶点

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CXADR/CAR His Tag Protein, Human

CXADR,CAR,CAR4/6,HCAR

价格 ￥1,000.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011106
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    CXADR, CAR, CAR4/6, HCAR

  • Accession

    NP_001329.1

  • 表达序列

    Leu20-Gly237 with His Tag at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    30-33kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Seuthe IMC, Krause L, Ruwe M, Silling S, Ehrhardt A, Eichhorn S, Ehrke-Schulz E, Park JJ. Expression and prognosis of DSG-2, CXADR, CD46 in head and neck squamous cell carcinoma. Pathol Res Pract. 2024 Oct; 262:155541.

背景介绍

  • Coxsackie virus and adenovirus receptor (CXADR), also known as CAR, is a type I transmembrane glycoprotein that serves as a receptor for group B coxsackie viruses and subgroup C adenoviruses. It belongs to the CTX family within the immunoglobulin (Ig) superfamily. CAR is strongly expressed in the developing central nervous system and functions as both a homophilic and heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins, including fibronectin, agrin, laminin-1, and tenascin-R.
    The human CXADR protein consists of a signal sequence, an extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a transmembrane segment, and an intracellular domain. The D1 domain is believed to be responsible for homodimer formation within tight junctions and is necessary and sufficient for adenovirus binding. Variants of CXADR are anchored to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of CXADR/CAR His Tag Protein, Human is more than 95% determined by SEC-HPLC.

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