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产品中心 药物靶点和Fc受体 药物靶点

IL-11 Rα Protein Fc Chimera, Human

IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 receptor subunit alpha,IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha

价格 ￥4,940.00 （ 1-2周）
货号 UA011103
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    IL-11 R alpha,IL-11 RA,IL11RA,Interleukin-11 receptor subunit alpha,IL-11 receptor subunit alpha,IL-11R subunit alpha,IL-11R-alpha

  • Accession

    Q14626-1

  • 表达序列

    Ser 24-Ala370 with C-terminus human IgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    70-90 kDa

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    ＜10 ng/mL by ELISA

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS pH7.4 with trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.

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