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产品中心 药物靶点和Fc受体 药物靶点

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CD24 Fc Chimera Protein, Cynomolgus

Signal transducer CD24,Ly-52,HAS,Nectadrin,R13-Ag,CD24,CD24A

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011099
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus

  • 分子别名

    Signal transducer CD24; Ly-52; HAS; Nectadrin; R13-Ag; CD24; CD24A

  • Accession

    I7GKK1-1

  • 表达序列

    Thr27-Lys54 with Human IgG1 Fc at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    40-55kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & ＞85% by SEC-HPLC

  • 活性

    Immobilized CD24 Fc Chimera Protein, Cynomolgus (Cat. No. UA011099) at 5.0μg/mL (100μL/well) can bind CD24 Recombinant Rabbit mAb (S-974-13) (Cat. No. S0B0725) with EC50 of 0.15-0.21μg/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
    2.Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.

背景介绍

  • Cluster of Differentiation 24 (CD24) is a mucin-type glycoprotein linked to the cell membrane via glycosylphosphatidylinositol (GPI). It is expressed on the surface of B-cells. Elevated levels of CD24 expression have been observed in various epithelial cancers, including ovarian, breast, non-small cell lung, prostate, and pancreatic cancers. CD24 plays a role in molecular adhesion and the spread of metastatic tumors, and it serves as a normal receptor for P-selectin. The CD24/P-selectin interaction may be significant in the dissemination of tumor cells by facilitating their interaction with platelets and endothelial cells. Furthermore, CD24 has been considered a potential tumor marker.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of CD24 Fc Chimera Protein, Cynomolgus is greater than 85% as determined by SEC-HPLC.

  • ELISA

    • Immobilized CD24 Fc Chimera Protein, Cynomolgus (Cat. No. UA011099) at 5.0μg/mL (100μL/well) can bind CD24 Recombinant Rabbit mAb (S-974-13) (Cat. No. S0B0725) with EC50 of 0.15-0.21μg/mL.

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