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产品中心 药物靶点和Fc受体 药物靶点

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C1qR1/CD93 Fc Chimera Protein, Human

AA4 Antigen,C1q R1,C1q receptor 1,C1q Rp,C1q/MBL/SPA receptor,C1qR(P),C1qR1,C1qRp,CD93 antigenC1qR,CD93 molecule,CD93,CDw93C1QR1,Collectin Receptor,Complement component 1 q subcomponent receptor 1,complement component 1,q subcomponent,receptor 1,complement component C1q receptor,dJ737E23.1,ECSM3,Ly68,Matrix-remodeling-associated protein 4,matrix-remodelling associated 4,MXRA4

价格 ￥1,200.00 （ 1-2周）
货号 UA011087
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    AA4 Antigen; C1q R1; C1q receptor 1; C1q Rp; C1q/MBL/SPA receptor; C1qR(P); C1qR1; C1qRp; CD93 antigenC1qR; CD93 molecule; CD93; CDw93C1QR1; Collectin Receptor; Complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4

  • Accession

    Q9NPY3

  • 表达序列

    Thr22-Lys580 with Human IgG1 Fc at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    100-120kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized C1qR1/CD93 Fc Chimera Protein, Human (Cat. No. UA011087) at 5.0μg/mL (100μL/well) can bind IGFBP-7 His Tag, Human (Cat. No. UA010394) with EC50 of 1.12-1.31μg/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Greenlee-Wacker M C. et al. (2011) Membrane-Associated CD93 Regulates Leukocyte Migration and C1q-Hemolytic Activity during Murine Peritonitis. J. Immunol. 187: 3353-3361.
    Nepomuceno R R. et al. (1997) cDNA cloning and primary structure analysis of C1qRp, the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. Immunity. 6: 119-129.
    Nepomuceno R R. et al. (1998) C1qRp, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets. J. Immunol. 160: 1929-1935.

背景介绍

  • Complement component 1q (C1q) receptor 1 (C1qR1, also known as C1qRp, or cluster of differentiation 93-CD93) is a 126-kDa type 1 transmembrane glycoprotein expressed in endothelial and hematopoietic cells, and responsible for C1q-induced phagocytosis. CD93 contains one C-type lectin domain and five EGF-like domains. Mature human CD93 consists of a 557 amino acid (aa) extracellular domain (ECD) with one C‑type lectin domain, four tandem EGF‑like domains, and a mucin‑like domain, followed by a 21 aa transmembrane segment and a 51 aa cytoplasmic domain. CD93 is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). Soluble CD93 promotes the differentiation of monocytes to macrophages, phagocytosis of apoptotic cells, and inflammatory responsiveness to multiple TLR ligands.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of C1qR1/CD93 Fc Chimera Protein, Human is greater than 95% as determined by SEC-HPLC.

  • ELISA

    • Immobilized C1qR1/CD93 Fc Chimera Protein, Human (Cat. No. UA011087) at 5.0μg/mL (100μL/well) can bind IGFBP-7 His Tag, Human (Cat. No. UA010394) with EC50 of 1.12-1.31μg/mL.

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