B7-2/CD86 His Tag Protein, Mouse
FUN-1,CTLA-4 counter-receptor B7.2,CD28LG2,Activation B7-2 antigen,CD86 Molecule,CD86 Antigen (CD28 Antigen Ligand 2,B7-2 Antigen),BU63,B70,B-Lymphocyte Activation Antigen B7-2,T-Lymphocyte Activation Antigen CD86,B-Lymphocyte Antigen B7-2,CD86 Antigen,LAB72,B7.2,B7-2 Antigen
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物种
Mouse分子别名
FUN-1，CTLA-4 counter-receptor B7.2，CD28LG2，Activation B7-2 antigen，CD86 Molecule，CD86 Antigen (CD28 Antigen Ligand 2， B7-2 Antigen)，BU63，B70，B-Lymphocyte Activation Antigen B7-2，T-Lymphocyte Activation Antigen CD86，B-Lymphocyte Antigen B7-2，CD86 Antigen，LAB72，B7.2，B7-2 AntigenAccession
Q549Q9表达序列
Val24-Glu245, with C-terminal His表达宿主
HEK293分子量
38-50kDa (Reducing)
纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg活性
Immobilized B7-2/CD86 His Tag Protein, Mouse (Cat. No. UA011072) at 2.0μg/mL (100μL/well) can bind CTLA-4/CD152 Fc Chimera Protein, Mouse (Cat. No. UA010773) with EC50 of 46.98-90.08ng/mL.标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, 5% trehalose, PH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Greenwald, R.J. et al. (2005) Annu. Rev. Immunol. 23:515.
2.Bour-Jordan, H. et al. (2011) Immunol. Rev. 241:180.
CD86, also known as B-lymphocyte activation antigen B7-2 (formerly referred to as B70), is a member of the cell surface immunoglobulin superfamily. Predominantly existing as a monomer on cell surfaces, B7-2 interacts with two co-stimulatory receptors: CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which are expressed on T cells. This interaction initiates signal pathways that regulate T cell activation and tolerance, cytokine production, and the generation of cytotoxic T lymphocytes (CTLs). B7 family members are transmembrane cell surface molecules that play crucial roles in immune activation and the maintenance of immune tolerance.
B7-2 is highly expressed on activated antigen-presenting cells (APCs), such as B cells, dendritic cells, and monocytes, as well as on vascular endothelial cells. B7-2 and its closely related counterpart, B7-1/CD80, exhibit overlapping yet distinct functional characteristics.
电泳
1μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
The purity of B7-2/CD86 His Tag Protein,Mouse is greater than 95% as determined by SEC-HPLC.
ELISA
Immobilized B7-2/CD86 His Tag Protein, Mouse (Cat. No. UA011072) at 2.0μg/mL (100μL/well) can bind CTLA-4/CD152 Fc Chimera Protein, Mouse (Cat. No. UA010773) with EC50 of 46.98-90.08ng/mL.
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