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产品中心 药物靶点和Fc受体 药物靶点

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MICA His Tag Protein, Human

FLJ60820,MGC111087,PERB11.1

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011069
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    FLJ60820; MGC111087; PERB11.1

  • Accession

    Q29983

  • 表达序列

    Glu24-Gln308, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    50-70kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & RP-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized NKG2D/CD314 Fc Chimera Protein, Human (Cat. No. UA010732) at 2.0μg/mL (100μL/well) can bind MICA His Tag Protein, Human (Cat. No. UA011069) with EC50 of 0.093-0.15μg/mL.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, 5% trehalose, PH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1. Journal List J Immunother Cancer v.7; 2019 .

背景介绍

  • MICA, a 383-amino-acid protein, interacts with the NKG2D receptor and the T cell receptor (TCR) to stimulate the activation of natural killer (NK) cells, αβ CD8 T cells, and γδ T cells. Typically undetectable in most cells, MICA is frequently found in epithelial tumors and its expression can be triggered by both bacterial and viral infections. The interaction between MICA and NKG2D leads to the activation of cytolytic functions and cytokine production in these effector cells, playing a crucial role in tumor surveillance, defense against viral infections, and the modulation of autoimmune responses.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of MICA His Tag Protein, Human is greater than 95% as determined by SEC-HPLC

  • ELISA

    • Immobilized NKG2D/CD314 Fc Chimera Protein, Human (Cat. No. UA010732) at 2.0μg/mL (100μL/well) can bind MICA His Tag Protein, Human (Cat. No. UA011069) with EC50 of 0.093-0.15μg/mL.

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