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物种
Human分子别名
FLJ60820; MGC111087; PERB11.1Accession
Q29983表达序列
Glu24-Gln308, with C-terminal His表达宿主
HEK293分子量
50-70kDa (Reducing)
纯度
＞95% by SDS-PAGE & RP-HPLC内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized powder缓冲体系
PBS, 5% trehalose, PH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1. Journal List J Immunother Cancer v.7; 2019 .
MICA, a 383-amino-acid protein, interacts with the NKG2D receptor and the T cell receptor (TCR) to stimulate the activation of natural killer (NK) cells, αβ CD8 T cells, and γδ T cells. Typically undetectable in most cells, MICA is frequently found in epithelial tumors and its expression can be triggered by both bacterial and viral infections. The interaction between MICA and NKG2D leads to the activation of cytolytic functions and cytokine production in these effector cells, playing a crucial role in tumor surveillance, defense against viral infections, and the modulation of autoimmune responses.
电泳(SDS-PAGE)
1μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
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The purity of MICA His Tag Protein, Human is greater than 95% as determined by SEC-HPLC
ELISA
Immobilized NKG2D/CD314 Fc Chimera Protein, Human (Cat. No. UA010732) at 2.0μg/mL (100μL/well) can bind MICA His Tag Protein, Human (Cat. No. UA011069) with EC50 of 0.093-0.15μg/mL.
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