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产品中心 药物靶点和Fc受体 药物靶点

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PSCA Fc Chimera Protein, Mouse

UNQ206,PRO232,Prostate stem cell antigen

价格 ￥1,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011066
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    UNQ206, PRO232,Prostate stem cell antigen

  • Accession

    P57096

  • 表达序列

    Leu21-Asn95, with N-terminal Fc

  • 表达宿主

    HEK293

  • 分子量

    38-53kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON. Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1735-40.
    Yang D, Holt GE, Velders MP, Kwon ED, Kast WM. Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice. Cancer Res. 2001 Aug 1;61(15):5857-60.

背景介绍

  • Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids. Mouse PSCA (mPsca) shares 65% homology with human PSCA at the nucleotide and amino acid levels. Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer. Knockdown of PSCA induced EMT and reduced metastatic potentials of the DU145 cells, suggesting that PSCA played an important role in prostatic carcinogenesis and progression.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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