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产品中心 药物靶点和Fc受体 药物靶点

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PSMA/FOLH1 Fc Chimera Protein, Human

GIG27,FOLH,NAALAD1,PSM,NAALADase I,GCPII,FGCP

价格 ￥1,580.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011064
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    GIG27, FOLH, NAALAD1, PSM, NAALADase I, GCPII, FGCP

  • Accession

    Q04609-1

  • 表达序列

    Lys44-Ala750 , with N-terminal Fc

  • 表达宿主

    HEK293

  • 分子量

    110-140kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized PSMA/FOLH1 Fc Chimera Protein, Human (Cat. No. UA011064) at 2.0μg/mL (100μL/well) can bind Biotinylated Anti-Human PSMA (Rosopatamab) with EC50 of 1.59-2.42ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Su S L. et al. (1995) Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression. Cancer Res. 55: 1441-1443.
    O'Keefe D S. et al. (1998) Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. Biochim Biophys Acta. 1443: 113-127.

背景介绍

  • Prostate-Specific Membrane Antigen (PSMA) is a transmembrane protein that is consistently found in prostatic tissues. Its expression is notably elevated in various malignancies, with prostate cancer exhibiting particularly high levels. In nearly all cases of prostate adenocarcinoma, PSMA is expressed in the majority of both primary and metastatic lesions.
    Immunohistochemical analysis has shown that PSMA expression intensifies in patients with dedifferentiated, metastatic, or hormone-refractory tumors. The level of PSMA expression has been correlated with the prognosis of the disease, offering significant predictive value for patient outcomes.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of PSMA/FOLH1 Fc Chimera Protein, Human is more than 95% determined by SEC-HPLC.

  • ELISA

    • Immobilized PSMA/FOLH1 Fc Chimera Protein, Human (Cat. No. UA011064) at 2.0μg/mL (100μL/well) can bind Biotinylated Anti-Human PSMA (Rosopatamab) with EC50 of 1.59-2.42ng/mL.

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