热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/3）

MICA Fc Chimera Protein, Human

MHC Class I Polypeptide-Related Sequence A,MIC-A, PERB11.1

价格 ￥1,280.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011057
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    MHC Class I Polypeptide-Related Sequence A; MIC-A; PERB11.1

  • Accession

    Q29983-1

  • 表达序列

    Glu24-Gln308, with C-terminal Fc

  • 表达宿主

    HEK293

  • 分子量

    80-95kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized NKG2D/CD314 His Tag Protein, Human (Cat. No. UA010938) at 2.0μg/mL (100μL/well) can bind MICA Fc Chimera Protein, Human (Cat. No. UA011057) with EC50 of 2.67-4.78ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Journal List J Immunother Cancer v.7; 2019 .

背景介绍

  • MICA is a protein of 383 amino acids and interacts with the NKG2D receptor and the T cell receptor (TCR) to activate NK cells, αβ CD8 T cells, and γδ T cells. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of MICA Fc Chimera Protein, Human is more than 95% determined by SEC-HPLC.

  • ELISA

    • Immobilized NKG2D/CD314 His Tag Protein, Human (Cat. No. UA010938) at 2.0μg/mL (100μL/well) can bind MICA Fc Chimera Protein, Human (Cat. No. UA011057) with EC50 of 2.67-4.78ng/mL.

评论(0)