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产品中心 药物靶点和Fc受体 药物靶点

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MSLN Fc Chimera Protein, Cynomolgus

CAK1,Mesothelin,MPF,MPFSMRP,SMR

价格 ￥1,480.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011043
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Cynomolgus

  • 分子别名

    CAK1; Mesothelin; MPF; MPFSMRP; SMR

  • Accession

    A0A2K5TW94(UniParc.UPI000C7396BF)

  • 表达序列

    Asp296-Gly580, with C-terminal Fc

  • 表达宿主

    HEK293

  • 分子量

    68-80kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Immobilized MSLN Fc Chimera Protein, Cynomolgus (Cat. No. UA011043) at 2.0μg/mL (100μL/well) can bind Biotinylated Anti-Human MSLN Monoclonal Antibody (Amatuximab) with EC50 of 4.66-7.64 ng/ mL.

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose，5% mannitol

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Chang K. et al. (1996) Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. PNAS. 93(1): 136-140.
    Liu X. et al. (2020) Multiple proteases are involved in mesothelin shedding by cancer cells. Commun Biol. 3: 728.

背景介绍

  • Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte potentiating factor, which belongs to the mesothelin family. Mesothelin/MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin/MSLN can interacts with MUC16. The membrane-anchored form of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro. Mesothelin (MSLN) is a lineage restricted cell surface protein expressed in about 30% of human cancers and high MSLN expression is associated with poor survival in several different cancers. The restricted expression of MSLN in normal tissue and its frequent expression in cancers make MSLN an excellent target for antibody-based therapies.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of MSLN Fc Chimera Protein, Cynomolgus is more than 95% determined by SEC-HPLC.

  • ELISA

    • Immobilized MSLN Fc Chimera Protein, Cynomolgus (Cat. No. UA011043) at 2.0μg/mL (100μL/well) can bind Biotinylated Anti-Human MSLN Monoclonal Antibody (Amatuximab) with EC50 of 4.66-7.64 ng/ mL.

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