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产品中心 药物靶点和Fc受体 药物靶点

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Bc1-w His Tag Protein, Human

Bcl-2-Like Protein 2,Bcl2-L-2,Apoptosis Regulator Bcl-W,BCL2L2,BCLW,KIAA0271

价格 ￥740.00 （ 1-2周）
货号 UA011025
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Bcl-2-Like Protein 2,Bcl2-L-2,Apoptosis Regulator Bcl-W,BCL2L2,BCLW,KIAA0271

  • Accession

    AAI13523.1

  • 表达序列

    Ala2-Thr172

  • 表达宿主

    E.coli

  • 分子量

    19.87 KDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Liquid

  • 缓冲体系

    25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5.

  • 储存条件

    • Store at ≤-70°C, stable for 6 months after receipt.
    • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
    • Please minimize freeze-thaw cycles.


背景介绍

  • Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

  • 电泳

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