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产品规格
物种
Human分子别名
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1,ITPRIPL1,KIAA1754L,CD3L1Accession
Q6GPH6表达序列
His25-Gly103, with C-terminal His表达宿主
HEK293分子量
10.1 KDa
纯度
＞95% by SDS-PAGE
内毒素含量
<1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4.溶解方法
- Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
- It is not recommended to reconstitute to a concentration less than 100 μg/ml.
- Dissolve the lyophilized protein in distilled water.
- Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
储存条件
- Lyophilized protein should be stored at ≤ -20℃, stable for one year after receipt.
- Reconstituted protein solution can be stored at 2-8℃ for 2-7 days.
- Aliquots of reconstituted samples are stable at ≤ -20℃ for 3 months.
背景介绍
Cancer immunotherapy has transformed treatment possibilities, but its effectiveness differs significantly among patients, indicating the presence of alternative pathways for immune evasion. Here, we show that ITPRIPL1 functions as an inhibitory ligand of CD3ε, and its expression inhibits T cells in the tumor microenvironment. 1,4,5-triphosphate receptor-interacting protein-like 1 (ITPRIPL1), a natural CD3 ligand, to evade immune surveillance and promote tumor growth. ITPRIPL1, is also a remarkable NSCLC biomarker. Detecting ITPRIPL1 in tumors can contribute to better diagnosis, CD8 positive T cell infiltration revelation, disease progression surveillance, and prognosis prediction.
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