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产品中心 药物靶点和Fc受体 药物靶点

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E-Selectin/CD62E His Tag Protein, Mouse

SELE,RP1-117P20.2,ELAM1,ESEL,LECAM2

价格 ￥1,280.00 （ 1-2周）
货号 UA011014
规格
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    SELE, RP1-117P20.2,ELAM1, ESEL, LECAM2

  • Accession

    Q00690

  • 表达序列

    Trp22Pro557, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    72-94KDa (Reducing)

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. The EC50 for this effect is less than 100 ng/ml.

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH 7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Matsumoto K, et al. (2010) Soluble adhesion molecule E-selectin predicts cardiovascular events in Japanese patients with type 2 diabetes mellitus. Metabolism. 59(3): 320-4.

    2.Stancanelli B, et al. (2010) Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients. Nephron Clin Pract. 114(1): c74-80.

背景介绍

  • E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes implicated in cancer cell metastasis. It has a complex mosaic structure that includes a large extracellular region with a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain. This is followed by a transmembrane region and a relatively short (32 amino acid) cytoplasmic tail. As part of the LEC-CAM or selectin family, E-selectin recognizes and binds to sialylated carbohydrates, including those from the Lewis X and Lewis A families, which are found on monocytes, granulocytes, and T-lymphocytes. It facilitates the rolling and stable arrest of leukocytes on activated vascular endothelium. Additionally, E-selectin is suggested to transduce activating stimuli via the MAPK signaling cascade during leukocyte adhesion.

  • 生物活性

    • Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. The EC50 for this effect is less than 100 ng/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of E-Selectin/CD62E His Tag Protein, Mouse is more than 95% determined by SEC-HPLC.

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