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产品中心 药物靶点和Fc受体 药物靶点

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Biotinylated VSIG4 Fc&Avi Tag Protein, Human

V-set and immunoglobulin domain-containing protein 4,Protein Z39Ig,Z39IG,CRIg

价格 ￥2,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA011000
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    V-set and immunoglobulin domain-containing protein 4, Protein Z39Ig, Z39IG, CRIg

  • Accession

    Q9Y279-1

  • 表达序列

    Arg20-Pro283 with Human IgG1 Fc & Avi Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    70-75kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE & RP-HPLC

  • 内毒素含量

    <1EU/μg

  • 活性

    Immobilized human iC3b at 5μg/mL (100μL/well) can bind Biotinylated VSIG4 Fc&Avi Tag Protein, Human(Cat. No. UA011000) with EC50 of 11.82-13.78 ng/mL.

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag, Avi Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Pan W, Huang W, Zheng J, Meng Z, Pan X. Construction of a prognosis model of head and neck squamous cell carcinoma pyroptosis and an analysis of immuno-phenotyping based on bioinformatics. Transl Cancer Res. 2024 Jan 31;13(1):299-316.
    Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H. VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production. Int J Biol Macromol. 2024 Mar;260(Pt 2):129357.

背景介绍

  • VSIG4 (V-set and immunoglobulin domain containing 4), also known as CRIg and Z39IG, is a type I transmembrane protein belonging to the B7 family within the immunoglobulin (Ig) superfamily. It features two Ig-like domains. VSIG4 is highly expressed in various fetal tissues, with the highest levels observed in the lung and placenta of adult tissues.
    VSIG4 serves as a negative regulator of T cell activation and is believed to play a role in maintaining peripheral T cell tolerance. Additionally, it has been identified as a potent suppressor of established inflammation. The protein acts as a phagocytic receptor and exerts a strong inhibitory effect on T-cell proliferation and IL-2 production.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • The purity of Biotinylated VSIG4 Fc&Avi Tag Protein, Human is more than 95% determined by RP-HPLC.

  • ELISA

    • Immobilized human iC3b at 5μg/mL (100μL/well) can bind Biotinylated VSIG4 Fc&Avi Tag Protein, Human(Cat. No. UA011000) with EC50 of 11.82-13.78 ng/mL.

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